Tuberin antibody (pThr1462)
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- Target See all Tuberin (TSC2) Antibodies
- Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))
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Binding Specificity
- pThr1462
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Tuberin antibody is un-conjugated
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Application
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- Phospho-Tuberin/TSC2 (Thr1462) Antibody detects endogenous levels of Tuberin/TSC2 only when phosphorylated at Threonine 1462.
- Predicted Reactivity
- Pig,Zebrafish,Bovine,Horse,Sheep
- Purification
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogen
- A synthesized peptide derived from human Tuberin/TSC2 around the phosphorylation site of Thr1462.
- Isotype
- IgG
- Top Product
- Discover our top product TSC2 Primary Antibody
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anti-Tuberous Sclerosis 2 (TSC2) (AA 1776-1805) antibody
TSC2 Reactivity: Human WB, IF, IHC (p) Host: Rabbit Polyclonal RB13393 unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 1611-1807) antibodyTSC2 Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 1601-1750) antibodyTSC2 Reactivity: Human, Mouse, Rat ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 1776-1805) antibodyTSC2 Reactivity: Human ELISA, WB, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (pSer1387) antibodyTSC2 Reactivity: Human DB, IF Host: Rabbit Polyclonal RB11388 unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 1397-1426) antibodyTSC2 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB42388 unconjugated
anti-Tuberous Sclerosis 2 (TSC2) antibodyTSC2 Reactivity: Human, Mouse, Rat IHC Host: Rabbit Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (Ser1798) antibodyTSC2 Reactivity: Human ELISA, WB, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 900-1150) antibodyTSC2 Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 1396-1496) antibodyTSC2 Reactivity: Human ELISA, WB, IF Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))
- Alternative Name
- TSC2 (TSC2 Products)
- Background
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Description: In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059). May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity).
Gene: TSC2
- Molecular Weight
- 200 kDa
- Gene ID
- 7249
- UniProt
- P49815
- Pathways
- RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus
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