The Rabbit Polyclonal anti-RAGE antibody (ABIN3029883) specifically detects RAGE in WB and ELISA.
The antibody is reactive with Human and Mouse samples.
Titration of the Rage antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
In 1X PBS, pH 7.4, with 0.09 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Aliquot the Rage antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Target
RAGE (AGER)
(Advanced Glycosylation End Product-Specific Receptor (AGER))
Alternative Name
Rage
Background
RAGE, the 'receptor for advanced glycation endproducts' is a transmembrane receptor of the immunoglobulin super family. The interaction between RAGE and its ligands, AGE and HMGB1, is thought to result in pro-inflammatory gene activation. Due to an enhanced level of RAGE ligands in diabetes or other chronic disorders, this receptor is hypothesised to have a causative effect in a range of inflammatory diseases such as diabetic complications, Alzheimer's disease and even some tumors. [Wiki]