Retinoblastoma Protein (Rb) antibody (AA 858-886)
Quick Overview for Retinoblastoma Protein (Rb) antibody (AA 858-886) (ABIN3029813)
Target
See all Retinoblastoma Protein (Rb) (Rb Protein) AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 858-886
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Purpose
- Retinoblastoma Antibody
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Cross-Reactivity (Details)
- Expected species reactivity: Rat
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Purification
- Purified
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Immunogen
- A portion of amino acids 858-886 from the human protein was used as the immunogen for this Retinoblastoma antibody.
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Isotype
- Ig Fraction
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Application Notes
- Titration of the Retinoblastoma antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Aliquot the Retinoblastoma antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
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Alternative Name
- Retinoblastoma
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Background
- RB1/Retinoblastoma is a negative regulator of the cell cycle and was the first tumor suppressor gene found. This protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1.
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UniProt
- P06400
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Pathways
- Mitotic G1-G1/S Phases
Target
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