RIPK3 antibody (AA 480-509)

Catalog No. ABIN3032447

The Rabbit Polyclonal anti-RIPK3 antibody has been validated for WB, IHC and ELISA. It is suitable to detect RIPK3 in samples from Human.

Quick Overview for RIPK3 antibody (AA 480-509) (ABIN3032447)

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RIPK3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-RIPK3 Antibody

Binding Specificity: AA 480-509

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 480-509 from the human protein was used as the immunogen for this RIPK3 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the RIPK3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the RIPK3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for RIPK3

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Alternative Name: RIPK3

Background: The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.

UniProt: Q9Y572

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades