SIRT5 antibody (AA 263-292)

Catalog No. ABIN3032595

This anti-SIRT5 antibody is a Rabbit Polyclonal antibody detecting SIRT5 in WB, IHC and ELISA. Suitable for Human.

Quick Overview for SIRT5 antibody (AA 263-292) (ABIN3032595)

Target: SIRT5 (Sirtuin 5 (SIRT5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIRT5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-SIRT5 Antibody

Binding Specificity: AA 263-292

Purification: Purified

Immunogen: A portion of amino acids 263-292 from the human protein was used as the immunogen for this SIRT5 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the SIRT5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:50-1:100,Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the SIRT5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for SIRT5

Target: SIRT5 (Sirtuin 5 (SIRT5))

Alternative Name: SIRT5

Background: SIRT5 is an NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity, however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. [UniProt]

UniProt: Q9NXA8

Pathways: SARS-CoV-2 Protein Interactome