MAP3K7 antibody (AA 574-606)

Catalog No. ABIN3032060

The Rabbit Polyclonal anti-MAP3K7 antibody is suitable to detect MAP3K7 in samples from Human. It has been validated for WB, ELISA and IHC.

Quick Overview for MAP3K7 antibody (AA 574-606) (ABIN3032060)

Target: MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-MAP3K7 Antibody

Binding Specificity: AA 574-606

Purpose: TAK1 Antibody / MAP3K7

Predicted Reactivity: Bovine,Mouse,Rat

Purification: Purified

Immunogen: A portion of amino acids 574-606 from the human protein was used as the immunogen for this TAK1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the TAK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles

Storage: -20 °C

Storage Comment: Aliquot the TAK1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for MAP3K7

Target: MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))

Alternative Name: TAK1

Background: TAK1 is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2, this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses.

UniProt: O43318

Pathways: NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway