TBK1 antibody (AA 8-35)

Catalog No. ABIN3029093

The Rabbit Polyclonal anti-TBK1 antibody has been validated for WB, ELISA. It is suitable to detect TBK1 in samples from Mouse.

Quick Overview for TBK1 antibody (AA 8-35) (ABIN3029093)

Target: TBK1 (TANK-Binding Kinase 1 (TBK1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TBK1 Antibody

Binding Specificity: AA 8-35

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 8-35 from the mouse protein was used as the immunogen for this Tbk1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Tbk1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Tbk1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for TBK1

Target: TBK1 (TANK-Binding Kinase 1 (TBK1))

Alternative Name: Tbk1

Background: Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of a TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response.

UniProt: Q9WUN2

Pathways: TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interactome