Transglutaminase 2 antibody (AA 413-442)

Catalog No. ABIN3029229

The Rabbit Polyclonal anti-Transglutaminase 2 antibody (ABIN3029229) specifically detects Transglutaminase 2 in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for Transglutaminase 2 antibody (AA 413-442) (ABIN3029229)

Target: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Transglutaminase 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Transglutaminase 2 Antibody

Binding Specificity: AA 413-442

Purpose: TG2 Antibody / Transglutaminase 2

Purification: SAS immunoprecipitation purified

Immunogen: A portion of amino acids 413-442 from the human protein was used as the immunogen for this TG2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the TG2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the TG2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Transglutaminase 2

Target: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Alternative Name: TG2

Background: Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. TGM2 acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. It has been identified as the autoantigen implicated in celiac disease.

UniProt: P21980

Pathways: Tube Formation, Thromboxane A2 Receptor Signaling