TXN antibody (AA 1-30)

Catalog No. ABIN3029119

This Rabbit Polyclonal antibody specifically detects TXN in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for TXN antibody (AA 1-30) (ABIN3029119)

Target: TXN (Thioredoxin (TXN))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXN antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TXN Antibody

Binding Specificity: AA 1-30

Purification: Purified

Immunogen: A portion of amino acids 1-30 from the human protein was used as the immunogen for this Thioredoxin antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Thioredoxin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Thioredoxin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for TXN

Target: TXN (Thioredoxin (TXN))

Alternative Name: Thioredoxin

Background: Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide isomerase(PDI) and a number of transcription factors such as p53, NF-kB and AP-1.Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.

UniProt: P10599

Pathways: Carbohydrate Homeostasis, Cell RedoxHomeostasis