YY1 antibody
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- Target See all YY1 Antibodies
- YY1 (YY1 Transcription Factor (YY1))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This YY1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Purification
- Purified
- Immunogen
- Purified His-tagged protein was used to produced this monoclonal YY1 antibody.
- Clone
- 1183CT6-5-23-6
- Isotype
- IgG2a
- Top Product
- Discover our top product YY1 Primary Antibody
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- Application Notes
- Titration of the YY1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Aliquot the YY1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Target
- YY1 (YY1 Transcription Factor (YY1))
- Alternative Name
- YY1 (YY1 Products)
- Synonyms
- yy1-a antibody, FIII antibody, MGC83714 antibody, yy1l antibody, zgc:64207 antibody, YY1 antibody, LOC494431 antibody, xyy1 antibody, delta antibody, nf-e1 antibody, ucrbp antibody, yin-yang-1 antibody, LOC100304682 antibody, ino80s antibody, yy1 antibody, DELTA antibody, INO80S antibody, NF-E1 antibody, UCRBP antibody, YIN-YANG-1 antibody, AW488674 antibody, fb59g10 antibody, wu:fa16g07 antibody, wu:fb59g10 antibody, YY1 transcription factor L homeolog antibody, YY1 transcription factor b antibody, YY1 transcription factor antibody, transcriptional repressor protein YY1 antibody, YY1 transcription factor S homeolog antibody, YY1 transcription factor a antibody, YY2 transcription factor antibody, yy1.L antibody, yy1b antibody, YY1 antibody, yy1 antibody, LOC100304682 antibody, yy1.S antibody, Yy1 antibody, yy1a antibody, YY2 antibody
- Background
- Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3', some genes have been shown to contain a longer binding motif allowing enhanced binding, the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair, proposed to target the INO80 complex to YY1-responsive elements.
- UniProt
- P25490
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