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KSR2 antibody

KSR2 Reactivity: Human, Mouse WB, IF, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN498345
  • Target See all KSR2 Antibodies
    KSR2 (Kinase Suppressor of Ras 2 (KSR2))
    Reactivity
    Human, Mouse
    Host
    • 39
    • 6
    Rabbit
    Clonality
    • 42
    • 3
    Polyclonal
    Conjugate
    • 19
    • 5
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KSR2 antibody is un-conjugated
    Application
    • 33
    • 30
    • 15
    • 13
    • 7
    • 5
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects endogenous levels of Kinase suppressor of Ras 2. (region surrounding Ile694)
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse.
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography
    Purity
    > 95 % by SDS-PAGE
    Top Product
    Discover our top product KSR2 Primary Antibody
  • Application Notes
    Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS) with 0.05 % Sodium azide, approx. pH 7.2.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    KSR2 (Kinase Suppressor of Ras 2 (KSR2))
    Alternative Name
    Kinase Suppressor of Ras 2 (KSR2 Products)
    Synonyms
    kinase suppressor of ras 2 antibody, KSR2 antibody, Ksr2 antibody
    Background
    Kinase suppressor of Ras (KSR) and MAP kinase kinase kinase (MEKK3) are integral members of the MAP kinase pathway. Ksr is a conserved protein that positively regulates Ras signaling and may function as a scaffold for Raf, MEK and ERK. There are two types of Ksr proteins: Ksr-1 and Ksr-2. These two are individually necessary for a few specific Ras-dependent processes, but they are required together for most aspects of Ras-mediated signaling. Ksr-2 plays a key role in Ras-mediated signaling during germline meiotic progression and functions redundantly with Ksr-1 during the development of the excretory system pathway, hermaphrodite vulva and male spicules. Ksr-2 also functions as a negative regulator of the MEKK3-mediated activation of the MAP kinase pathways (specifically ERK and JNK) and of the NFκB pathways, and it simultaneously inhibits MEKK3-mediated IL-8 production.Synonyms: KSR-2, KSR2, hKSR-2, hKSR2
    Molecular Weight
    approx. 108 kDa
    Gene ID
    283455
    NCBI Accession
    NP_775869
    UniProt
    Q6VAB6
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