RPS6KA6 antibody

Catalog No. ABIN498435

Product Details anti-RPS6KA6 Antibody

Target: RPS6KA6 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6 (RPS6KA6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPS6KA6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: This antibody detects endogenous levels of Rsk-4 protein. (region surrounding Gln688)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography

Purity: > 95 % by SDS-PAGE

Application Details

Application Notes: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for RPS6KA6

Target: RPS6KA6 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6 (RPS6KA6))

Alternative Name: RPS6KA6 / RSK4 (RPS6KA6 Products)

Synonyms: PP90RSK4 antibody, RSK4 antibody, 2610524K04Rik antibody, RGD1560817 antibody, ribosomal protein S6 kinase A6 antibody, ribosomal protein S6 kinase polypeptide 6 antibody, RPS6KA6 antibody, Rps6ka6 antibody

Background: The family of ribosomal S6 kinases (Rsks), designated Rsk-1 (MAPKAP kinase-1), Rsk-2 and Rsk-3, are intracellular serine/threonine kinases that are important signaling intermediates in response to a broad range of ligand activated receptor tyrosine kinases. A unique feature common to the members of the Rsk family is that each possesses two non-identical complete kinase catalytic domains. An additional Rsk protein, Rsk-4, shows a high level of homology to the three previously isolated members of the human Rsk family. Rsk-4 is most abundantly expressed in brain and kidney and plays a role in normal neuronal development. The 70 kDa family of ribosomal S6 kinases includes p70 S6 kinase and p70 S6 kinase beta, which are thought to have similar regulatory functions. MSK1 (also designated RLPK) is a novel Rskrelated protein, which, like the p90 Rsk family members, contains two non-identical complete kinase catalytic domains.Synonyms: 90 kDa ribosomal protein S6 kinase 6, RSK-4, Ribosomal S6 kinase 4, Ribosomal protein S6 kinase alpha-6, S6K-alpha-6, p90-RSK 6, p90RSK6, pp90RSK4

Molecular Weight: approx. 84 kDa

Gene ID: 27330

NCBI Accession: NP_055311

UniProt: Q9UK32

Pathways: MAPK Signaling