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CEP290 antibody
CEP290
Reactivity: Human, Mouse
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-CEP290 Antibody
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Target
See all CEP290 Antibodies
CEP290
(Centrosomal Protein 290kDa (CEP290))
Reactivity
All reactivities for CEP290 antibodies
Human, Mouse
Host
All hosts for CEP290 antibodies
Rabbit
Clonality
All clonalities for CEP290 antibodies
Polyclonal
Conjugate
All conjugates for CEP290 antibodies
This CEP290 antibody is un-conjugated
Application
All applications for CEP290 antibodies
Western Blotting (WB)
Specificity
This antibody detects endogenous levels of CEP290 protein. (region surrounding Phe812)
Cross-Reactivity (Details)
Species reactivity (tested):Human and Mouse.
Purification
Affinity Chromatography using epitope-specific immunogen.
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Alternatives
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Application Details
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Application Notes
Western Blot: 1/500 - 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Concentration
1.0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for CEP290
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Target
CEP290
(Centrosomal Protein 290kDa (CEP290))
Alternative Name
CEP290 (CEP290 Products )
Synonyms
ct87 antibody, mks4 antibody, rd16 antibody, bbs14 antibody, jbts5 antibody, jbts6 antibody, lca10 antibody, nphp6 antibody, slsn6 antibody, sh11ag antibody, MGC81471 antibody, 3h11ag antibody, RGD1311640 antibody, BC004690 antibody, Nphp6 antibody, b2b1454Clo antibody, b2b1752Clo antibody, im:7145703 antibody, im:7147820 antibody, 3H11Ag antibody, BBS14 antibody, CT87 antibody, JBTS5 antibody, LCA10 antibody, MKS4 antibody, NPHP6 antibody, POC3 antibody, SLSN6 antibody, centrosomal protein 290 antibody, centrosomal protein 290 L homeolog antibody, centrosomal protein 290kDa antibody, CEP290 antibody, cep290.L antibody, cep290 antibody, Cep290 antibody
Background
CEP290 activates ATF4 mediated transcription and is required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells, may play a role in ciliary transport processes. CEP290 is ubiquitously expressed, strongly in placenta and weakly in brain. There are two named isoforms. Defects in CEP290 are a cause of Joubert syndrome type 5 (JBTS5) [MIM:610188], Senior-Loken syndrome type 6 (SLSN6) [MIM:610189], Leber congenital amaurosis type 10 (LCA10) [MIM:611755] and Meckel syndrome type 4 (MKS4) [MIM:611134]. Antibodies against CEP290 are present in sera from patients with cutaneous T cell lymphomas, but not in the healthy control population.Synonyms: CT87, Cancer/testis antigen 87, Centrosomal protein of 290 kDa, KIAA0373, NPHP6, Nephrocystin-6, Tumor antigen se2-2, se2-2
Molecular Weight
approx. 290 kDa
Gene ID
80184
NCBI Accession
NP_079390
UniProt
O15078
Pathways
cAMP Metabolic Process , M Phase
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