GGH antibody

Catalog No. ABIN499075

This Rabbit Polyclonal antibody specifically detects GGH in WB. It exhibits reactivity toward Human.

Quick Overview for GGH antibody (ABIN499075)

Target: GGH (gamma-Glutamyl Hydrolase (Conjugase, Folylpolygammaglutamyl Hydrolase) (GGH))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GGH antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GGH Antibody

Specificity: This antibody detects endogenous levels of GGH protein. (region surrounding Lys287)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography using epitope-specific immunogen

Purity: > 95 % (by SDS-PAGE)

Application Details

Application Notes: Western blot: 1: 500 - 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for GGH

Target: GGH (gamma-Glutamyl Hydrolase (Conjugase, Folylpolygammaglutamyl Hydrolase) (GGH))

Alternative Name: gamma-Glutamyl Hydrolase / GGH

Background: GGH (gamma-glutamyl hydrolase), also known as GH or Gamma-Glu-X carboxypeptidase, is a 318 amino acid protein that is secreted into the extracellular space and is also localized to both the lysosome and the melanosome. Functioning as a hydrolase, GGH contains one gamma-glutamyl hydrolase domain through which it catalyzes the hydrolysis of polyglutamate sidechains from pteroylpolyglutamates, specifically hydrolyzing gamma-glutamyl bonds. Via its catalytic activity, GGH may play a role in the bioavailability and metabolic activity of pteroylpolyglutamates. Polymorphisms in the gene encoding GGH are associated with rheumatoid arthritis, inflammatory bowel disease and various cancers.Synonyms: Conjugase, GH, Gamma-Glu-X carboxypeptidase

Molecular Weight: approx. 36 kDa

Gene ID: 8836

NCBI Accession: NP_003869

UniProt: Q92820

Pathways: SARS-CoV-2 Protein Interactome