TSTA3 antibody

Catalog No. ABIN499078

This Rabbit Polyclonal antibody specifically detects TSTA3 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TSTA3 antibody (ABIN499078)

Target: TSTA3 (Tissue Specific Transplantation Antigen P35B (TSTA3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSTA3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TSTA3 Antibody

Specificity: This antibody detects endogenous levels of FX protein.

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography using epitope-specific immunogen

Purity: > 95 % (by SDS-PAGE)

Application Details

Application Notes: Western blot: 1: 500 - 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for TSTA3

Target: TSTA3 (Tissue Specific Transplantation Antigen P35B (TSTA3))

Alternative Name: TSTA3

Background: GDP-L-fucose synthetase (FX protein), also designated Tissue-specific transplantation antigen P35B or GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, belongs to the fucose synthetase family. FX is a red cell NADP(H)- binding protein that is important in leukocyte adhesion and trafficking processes. The FX protein, together with GDP-mannose 4,6-dehydratase, can convert GDP-mannose to GDP-L-fucose by catalyzing the two-step epimerase and reductase reactions. GDP-L-fucose is the substrate of several fucosyltransferases that function in the expression of many glycoconjugates such as blood group ABH antigens and developmental adhesion antigens. Defects in the gene encoding for the FX protein cause leukocyte adhesion deficiency (LAD).Synonyms: 5-epimerase-4-reductase, GDP-4-keto-6-deoxy-D-mannose-3, GDP-L-fucose synthetase, Protein FX, Red cell NADP(H)-binding protein, SDR4E1, Short chain dehydrogenase/reductase family 4E member 1

Molecular Weight: approx. 40 kDa

Gene ID: 7264

NCBI Accession: NP_003304

UniProt: Q13630