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BACE2 antibody (C-Term)

BACE2 Reactivity: Human WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499397
  • Target See all BACE2 Antibodies
    BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))
    Binding Specificity
    • 15
    • 8
    • 8
    • 7
    • 6
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 50
    • 34
    • 13
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 68
    • 3
    • 1
    Rabbit
    Clonality
    • 70
    • 2
    Polyclonal
    Conjugate
    • 32
    • 11
    • 8
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BACE2 antibody is un-conjugated
    Application
    • 53
    • 35
    • 25
    • 13
    • 13
    • 11
    • 8
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    BACE2 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human BACE2.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    Human BACE2 (C-Terminus) Peptide
    Isotype
    IgG
    Top Product
    Discover our top product BACE2 Primary Antibody
  • Application Notes
    ELISA. Western Blot: BACE2 antibody can be used for detection of BACE2 at 0.5 to 1 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))
    Alternative Name
    BACE2 (BACE2 Products)
    Synonyms
    AEPLC antibody, ALP56 antibody, ASP1 antibody, ASP21 antibody, BAE2 antibody, CEAP1 antibody, DRAP antibody, 1110059C24Rik antibody, AI850424 antibody, ARP1 antibody, CDA13 antibody, beta-site APP-cleaving enzyme 2 antibody, BACE2 antibody, Bace2 antibody
    Background
    Accumulation of the amyloid-beta (alphabetaβ) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. alphabeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4-9). BACE2 also cleaves APP at b-site and at a different site within alphabeta (8). BACE2 locates on chromosome 21q22.3, the so-called 'Down critical region', suggesting that BACE2 and alphabeta may also contribute to the pathogenesis of Down syndrome (6,7)Synonyms: AEPLC, ALP56, ASP1, ASP21, Aspartic-like protease 56 kDa, Aspartyl protease 1, Beta-secretase 2, Beta-site APP-cleaving enzyme 2, Down region aspartic protease, Memapsin-1, Membrane-associated aspartic protease 1
    Gene ID
    25825
    UniProt
    Q9Y5Z0
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