CUEDC2 antibody (C-Term)

Catalog No. ABIN499688

The Rabbit Polyclonal anti-CUEDC2 antibody is suitable to detect CUEDC2 in samples from Human, Mouse and Rat. It has been validated for WB, IF and EIA.

Quick Overview for CUEDC2 antibody (C-Term) (ABIN499688)

Target: CUEDC2 (CUE Domain Containing 2 (CUEDC2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CUEDC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-CUEDC2 Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to CUEDC2.

Purification: Affinity chromatography purified via peptide column

Immunogen: CUEDC2 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human CUEDC2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: CUEDC2 antibody can be used for detection of CUEDC2 at 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for CUEDC2

Target: CUEDC2 (CUE Domain Containing 2 (CUEDC2))

Alternative Name: CUEDC2

Background: The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, ~40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation. CUE domains are present in eukaryotic proteins that are involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found. CUEDC2 (CUE domain-containing protein 2) was found through a yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway. CUEDC2 also decreases the sumoylation of PR. CUEDC2 has also been found to interact with IKK-a and IKK-b and decrease the activation of NF-kB by decreasing the activation of IKK. CUEDC2 antibody will not cross-react with CUEDC1.Synonyms: C10orf66, CUE domain-containing protein 2, HOYS6

Gene ID: 79004

NCBI Accession: NP_076945

UniProt: Q9H467