DCLK3 antibody (N-Term)

Catalog No. ABIN499720

This Rabbit Polyclonal antibody specifically detects DCLK3 in WB and EIA. It exhibits reactivity toward Human and Mouse.

Quick Overview for DCLK3 antibody (N-Term) (ABIN499720)

Target: DCLK3 (Doublecortin-Like Kinase 3 (DCLK3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCLK3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-DCLK3 Antibody

Binding Specificity: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: DCLK3 antibody was raised against a 14 amino acid peptide near the amino terminus of human DCLK3.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 1 - 2 μg/mL. Immunofluorescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for DCLK3

Target: DCLK3 (Doublecortin-Like Kinase 3 (DCLK3))

Alternative Name: Doublecortin-Like Kinase 3

Background: DCLK3 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK3 mRNA, like that of the homologous DCLK1 and DCLK3, is highly expressed in adult brain, but only DCLK3 transcripts are present in liver and kidney, suggesting that DCLK3 may play other roles than in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a protein that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization.Synonyms: DCAMKL3, DCDC3C, DCK3, DCLK3, KIAA1765, Serine/threonine-protein kinase DCLK3

Gene ID: 85443

NCBI Accession: NP_208382

UniProt: Q9C098