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LGI4 antibody (C-Term)

LGI4 Reactivity: Human, Mouse, Rat WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500160
  • Target See all LGI4 Antibodies
    LGI4 (Leucine-Rich Repeat LGI Family, Member 4 (LGI4))
    Binding Specificity
    • 15
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 27
    • 9
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    Human, Mouse, Rat
    Host
    • 27
    • 2
    Rabbit
    Clonality
    • 27
    • 2
    Polyclonal
    Conjugate
    • 11
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LGI4 antibody is un-conjugated
    Application
    • 24
    • 13
    • 13
    • 10
    • 4
    • 4
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects LGI4 at C-term (only the larger form). It is predicted to be specific to LGI4 and not recognize other LGI proteins.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogen
    LGI4 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human LGI4.
    Isotype
    IgG
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  • Application Notes
    ELISA. Western blot: 1 - 2 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    LGI4 (Leucine-Rich Repeat LGI Family, Member 4 (LGI4))
    Alternative Name
    LGI4 (LGI4 Products)
    Synonyms
    Lgil3 antibody, clp antibody, LGIL3 antibody, leucine rich repeat LGI family member 4 antibody, leucine-rich repeat LGI family, member 4 antibody, LGI4 antibody, Lgi4 antibody
    Background
    The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI4 have not been found to be associated with ADTLE. However, the LGI4 gene is located in a region linked to benign familial infantile convulsions. Further study revealed that a GC-to-AT polymorphism was correlated with childhood absence epilepsy. Other studies showed that decreasing LGI4 expression in cultured cells inhibits myelination, indicating that LGI4 may play a role in neural development. Two isoforms of LGI4 are known to exist.Synonyms: LGI1-like protein 3, LGI4, LGIL3, Leucine-rich glioma-inactivated protein 4, Leucine-rich repeat LGI family member 4
    Gene ID
    163175
    UniProt
    Q8N135
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