Nanos Homolog 1 antibody (N-Term)

Catalog No. ABIN500316

Product Details anti-Nanos Homolog 1 Antibody

Target: Nanos Homolog 1 (NANOS1)

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nanos Homolog 1 antibody is un-conjugated

Application: Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Specificity: This antibody detects NANOS1 at N-term.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Peptide affinity chromatography

Immunogen: Nanos1 antibody was raised against a 17 amino acid peptide from near the amino terminus of human Nanos1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for Nanos Homolog 1

Target: Nanos Homolog 1 (NANOS1)

Alternative Name: NANOS1 (NANOS1 Products)

Synonyms: NOS1 antibody, nanos1 antibody, fb76c12 antibody, wu:fb93h11 antibody, wu:fb98e07 antibody, wu:fq21a10 antibody, Xcat-2 antibody, nos1 antibody, xnos1 antibody, xcat-2 antibody, LOC100144352 antibody, NANOS1A antibody, nanos C2HC-type zinc finger 1 antibody, nanos homolog 1 antibody, nanos homolog 1 (Drosophila) antibody, nanos homolog 1 L homeolog antibody, Nanos homolog 1 antibody, nanos1 antibody, NANOS1 antibody, nanos1 antibody, Nanos1 antibody, nanos1.L antibody, nano1 antibody, nanos1a antibody

Background: Nanos1 is one of three known mammalian homologs to the Drosophila gene nanos. Nanos1 is an RNA-binding protein containing a zinc-finger motif and is expressed in the developing nervous system and continues in the adult brain. Interestingly, unlike mice deficient in either nanos2 or nanos3, mice lacking the nanos1 gene develop normally with no sign of abnormalities. Recently it has been found that expression of nanos1 mRNA is down-regulated by E-cadherin in a human breast cancer cell line and the amino-terminal domain on Nanos1 interacts with the E-cadherin-binding protein p120ctn. Furthermore, overexpression of Nanos1 in human colorectal DLD1 cancer cells functionally abolished cell-cell adhesion, allowing the cancer cells to develop strong migratory and invasive properties. These results suggest that targeting Nanos1 might prove an effective strategy in the treatment of E-cadherin-negative tumors.Synonyms: NOS1, Nanos homolog 1

Gene ID: 340719

UniProt: Q8WY41

Pathways: Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction