CBX3 antibody (pSer93) (AbBy Fluor® 680)

Catalog No. ABIN5004830

This anti-CBX3 antibody is a Rabbit Polyclonal antibody detecting CBX3 in IF (cc) and IF (p). Suitable for Human.

Quick Overview for CBX3 antibody (pSer93) (AbBy Fluor® 680) (ABIN5004830)

Target: CBX3 (Chromobox Homolog 3 (CBX3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBX3 antibody is conjugated to AbBy Fluor® 680

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-CBX3 Antibody (AbBy Fluor® 680)

Binding Specificity: pSer93

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human HP1 gamma around the phosphorylation site of Ser83

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CBX3

Target: CBX3 (Chromobox Homolog 3 (CBX3))

Alternative Name: HP1 gamma

Background:

Synonyms: HP1 gamma phospho S93, HP1 gamma phospho Ser93, p-HP1 gamma Ser93, CBX 3, CBX3, Chromobox homolog 3, Chromobox protein homolog 3, HECH, Heterochromatin like protein 1, Heterochromatin protein 1 homolog gamma, Heterochromatin protein HP1 gamma, HP1 gamma homolog, HP1Hs gamma , Modier 2, protein HP1-GAMMA, HP1g, M32, HP1 gamma, MGC118084, CBX3_HUMAN, Modier 2 protein.

Background: HP1 gamma appears to be involved in transcriptional silencing in heterochromatin-like complexes. It recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. HP1 gamma may contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR) and involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Gene ID: 11335