PRTFDC1 antibody (Center)

Catalog No. ABIN500545

Product Details anti-PRTFDC1 Antibody

Target: PRTFDC1 (phosphoribosyl Transferase Domain Containing 1 (PRTFDC1))

Binding Specificity: Center

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRTFDC1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects PRTFDC1.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogen: PRTFDC1 antibody was raised against a 14 amino acid peptide from near the center of human PRTFDC1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 0.5 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for PRTFDC1

Target: PRTFDC1 (phosphoribosyl Transferase Domain Containing 1 (PRTFDC1))

Alternative Name: PRTFDC1 (PRTFDC1 Products)

Synonyms: HHGP antibody, HPRT antibody, hprt1 antibody, hprt1l antibody, zgc:55561 antibody, zgc:86771 antibody, MGC80959 antibody, OTTMUSG00000011667 antibody, Prtfdc1 antibody, phosphoribosyl transferase domain containing 1 antibody, phosphoribosyl transferase domain containing 1 L homeolog antibody, phosphoribosyltransferase domain containing 1 pseudogene antibody, PRTFDC1 antibody, prtfdc1 antibody, Prtfdc1 antibody, prtfdc1.L antibody, Gm13377 antibody

Background: Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.Synonyms: HHGP, Phosphoribosyltransferase domain-containing protein 1

Gene ID: 56952

NCBI Accession: NP_064585

UniProt: Q9NRG1

Pathways: Ribonucleoside Biosynthetic Process