JUP antibody (pTyr550) (AbBy Fluor® 750)

Catalog No. ABIN5005702

The Rabbit Polyclonal anti-JUP antibody has been validated for IF (cc) and IF (p). It is suitable to detect JUP in samples from Human.

Quick Overview for JUP antibody (pTyr550) (AbBy Fluor® 750) (ABIN5005702)

Target: JUP (Junction Plakoglobin (JUP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JUP antibody is conjugated to AbBy Fluor® 750

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-JUP Antibody (AbBy Fluor® 750)

Binding Specificity: pTyr550

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human JUP around the phosphorylation site of Tyr550

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for JUP

Target: JUP (Junction Plakoglobin (JUP))

Alternative Name: JUP

Background:

Synonyms: gamma Catenin phospho Y550, p-gamma Catenin phospho Y550, catenin cadherin-associated protein gamma 80kD, Catenin gamma, CTNNG, Desmoplakin 3, Desmoplakin III, Desmoplakin3, DesmoplakinIII, DP 3, DP III, DP3, DPIII, gamma catenin, Junction plakoglobin, JUP, PDGB, PKGB, PLAKOGLOBIN.

Background: Gamma Catenin is a common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of gamma Catenin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. It is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat.

Gene ID: 3728

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location