RGS21 antibody (Center)

Catalog No. ABIN500587

Product Details anti-RGS21 Antibody

Target: RGS21 (Regulator of G-Protein Signaling 21 (RGS21))

Binding Specificity: Center

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RGS21 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects RGS21.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Peptide Affinity Chromatography

Immunogen: RGS21 antibody was raised against a 16 amino acid peptide near the center of Human RGS21.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1-2 μg/mL (HepG2 cells as recommended Positive Control). Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for RGS21

Target: RGS21 (Regulator of G-Protein Signaling 21 (RGS21))

Alternative Name: RGS21 (RGS21 Products)

Synonyms: EG624910 antibody, regulator of G protein signaling 21 antibody, regulator of G-protein signaling 21 antibody, regulator of G-protein signalling 21 antibody, RGS21 antibody, Rgs21 antibody

Background: Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit. RGS21 is a recently identified member of this family that has been reported to be selectively expressed in subpopulations of taste bud cells and co-expressed with bitter and sweet transduction components such as alpha-gusticin, phospholipase Cbeta2, T1R2/T1R3 sweet taste receptors and T2R bitter taste receptors. Other reports indicate that RGS21 is more widely expressed. Binding assays demonstrate that RGS21 binds alpha-gusticin in a conformation-dependent manner and may do the same with T1R receptors, suggesting that RGS21 may play a role in sweet and bitter taste transduction processes.Synonyms: Regulator of G-protein signaling 21

Gene ID: 431704

NCBI Accession: NP_001034241

UniProt: Q2M5E4

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling