SARM1 antibody (C-Term)

Catalog No. ABIN500660

The Rabbit Polyclonal anti-SARM1 antibody has been validated for WB, IF and EIA. It is suitable to detect SARM1 in samples from Human and Mouse. There are 2+ publications available.

Quick Overview for SARM1 antibody (C-Term) (ABIN500660)

Target: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SARM1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-SARM1 Antibody

Binding Specificity: C-Term

Specificity: This antibody detects SARM1 at C-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Ion exchange chromatography

Immunogen: SARM antibody was raised against a peptide corresponding to amino acids near the C- terminus of human SARM.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 0.5 to 2 μg/mL. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

References for anti-SARM1 antibody (ABIN500660)

Chintala, Putris, Geno: "Activation of TLR3 promotes the degeneration of retinal ganglion cells by upregulating the protein levels of JNK3." in: Investigative ophthalmology & visual science, Vol. 56, Issue 1, pp. 505-14, (2015) (PubMed).

Massoll, Mando, Chintala: "Excitotoxicity upregulates SARM1 protein expression and promotes Wallerian-like degeneration of retinal ganglion cells and their axons." in: Investigative ophthalmology & visual science, Vol. 54, Issue 4, pp. 2771-80, (2013) (PubMed).

Target Details for SARM1

Target: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Alternative Name: SARM1

Background: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SARM (SAM and ARM-containing protein), along with other molecules such as TIRP, TRIF, TIRAP, and MyD88, is thought to serve as an adaptor protein for the TLRs that allows for the activation of downstream kinases and NF-kappaB, and ultimately the expression of proteins involved in host defense. While SARM has not been conclusively shown to associate directly with TLRs, the presence of a Toll-interluekin-1 (TIR) domain in SARM is consistent with a role as a signaling molecule.Synonyms: KIAA0524, SAM domain-containing protein 2, SAMD2, SARM, Sterile alpha and Armadillo repeat protein, Sterile alpha and TIR motif-containing protein 1, Sterile alpha motif domain-containing protein 2

Gene ID: 23098

NCBI Accession: NP_055892

UniProt: Q6SZW1

Pathways: TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades