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SATB1 antibody (C-Term)

SATB1 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500670
  • Target See all SATB1 Antibodies
    SATB1 (SATB Homeobox 1 (SATB1))
    Binding Specificity
    • 16
    • 8
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 61
    • 46
    • 27
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 56
    • 4
    • 1
    Rabbit
    Clonality
    • 47
    • 14
    Polyclonal
    Conjugate
    • 31
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SATB1 antibody is un-conjugated
    Application
    • 28
    • 22
    • 14
    • 14
    • 12
    • 12
    • 10
    • 6
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects SATB1 at C-term.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogen
    SATB1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human SATB1.
    Isotype
    IgG
    Top Product
    Discover our top product SATB1 Primary Antibody
  • Application Notes
    ELISA. Western blot: 2 - 4 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    SATB1 (SATB Homeobox 1 (SATB1))
    Alternative Name
    SATB1 (SATB1 Products)
    Synonyms
    2610306G12Rik antibody, AW413156 antibody, SATB1 antibody, sb:cb955 antibody, si:ch211-195k18.2 antibody, SATB homeobox 1 antibody, special AT-rich sequence binding protein 1 antibody, SATB homeobox 1a antibody, SATB1 antibody, Satb1 antibody, satb1 antibody, satb1a antibody
    Background
    Human special AT-rich sequence-binding protein-1 (SATB1) is a nuclear matrix/scaffold-associated region DNA-binding protein, predominantly expressed in the thymus and pre-B cells. Like its homolog SATB2, SATB1 selectively binds double-stranded, special AT-rich DNA sequences in which one strand exclusively consists of well-mixed A, T, and C nucleotides. SATB1 contains a dimerization domain that shares similarity with the PDZ motif, identified as an indispensable element for high-affinity binding of SATB1 to DNA. SATB1 constitutes a functional nuclear architecture that has a \'cage-like\' protein distribution surrounding heterochromatin and regulates gene expression through chromatin remodeling/HDAC (histone deacetylase complex) and transcription factors recruitment. SATB1 functions as a \'genome organizer\' essential for proper T-cell development. Recent studies show that SATB1 is necessary for breast cancer cells to become metastatic, and when ectopically expressed in non-metastatic cells, can induce invasive activity in vivo. At least two isoforms of SATB1 are known to exist.Synonyms: DNA-binding protein SATB1, Special AT-rich sequence-binding protein 1
    Gene ID
    6304
    UniProt
    Q01826
    Pathways
    Caspase Cascade in Apoptosis, Activated T Cell Proliferation
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