NUMB antibody (pSer276) (AbBy Fluor® 750)

Catalog No. ABIN5007946

The Rabbit Polyclonal anti-NUMB antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect NUMB in samples from Mouse.

Quick Overview for NUMB antibody (pSer276) (AbBy Fluor® 750) (ABIN5007946)

Target: NUMB (Numb Homolog (NUMB))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUMB antibody is conjugated to AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-NUMB Antibody (AbBy Fluor® 750)

Binding Specificity: pSer276

Specificity: This phosphorylation site is homologous to that of Ser276 in Mouse and Ser275 in Rat.

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Numb around the phosphorylation site of Ser276

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NUMB

Target: NUMB (Numb Homolog (NUMB))

Alternative Name: Numb

Background:

Synonyms: S171, C14orf41, c14_5527, Protein numb homolog, h-Numb, Protein S171, NUMB

Background: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.

Gene ID: 8650

UniProt: P49757

Pathways: Cell-Cell Junction Organization