SPRED2 antibody (Center)
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- Target See all SPRED2 Antibodies
- SPRED2 (Sprouty-Related, EVH1 Domain Containing 2 (SPRED2))
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Binding Specificity
- Center
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SPRED2 antibody is un-conjugated
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificity
- This antibody detects SPRED2. It is predicted to have no cross-reactivity to Spred1 or Spred3.
- Cross-Reactivity (Details)
- Species reactivity (tested):Human
- Purification
- Peptide affinity chromatography
- Immunogen
- Spred2 antibody was raised against a 13 amino acid peptide near the center of the human Spred2.
- Isotype
- IgG
- Top Product
- Discover our top product SPRED2 Primary Antibody
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- Application Notes
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ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- PBS containing 0.02 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- Target
- SPRED2 (Sprouty-Related, EVH1 Domain Containing 2 (SPRED2))
- Alternative Name
- SPRED2 (SPRED2 Products)
- Background
- Spred2 is a member of the Sprouty family, a group of proteins that act as negative regulators during development. Like Spred1, Spred2 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. At least two isoforms of Spred2 are known to exist.Synonyms: MGC163164, Spred-2, Sprouty-related EVH1 domain containing 2
- Gene ID
- 200734
- NCBI Accession
- NP_861449
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