TTBK2 antibody (AA 1151-1244) (AbBy Fluor® 750)

Catalog No. ABIN5012069

This anti-TTBK2 antibody is a Rabbit Polyclonal antibody detecting TTBK2 in WB, IF (cc), IF (p). Suitable for Human.

Quick Overview for TTBK2 antibody (AA 1151-1244) (AbBy Fluor® 750) (ABIN5012069)

Target: TTBK2 (tau Tubulin Kinase 2 (TTBK2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TTBK2 antibody is conjugated to AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-TTBK2 Antibody (AbBy Fluor® 750)

Binding Specificity: AA 1151-1244

Predicted Reactivity: Human,Mouse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TTBK2/SCA11

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for TTBK2

Target: TTBK2 (tau Tubulin Kinase 2 (TTBK2))

Alternative Name: TTBK2/SCA11

Background:

Synonyms: TTBK2/SCA11 Tau tubulin kinase 2, Spinocerebellar ataxia 11, Tau tubulin kinase 2, Tau-tubulin kinase 2, TTBK, TTBK 2, TTBK1, TTBK2 , TTBK2_HUMAN, TTK, KIAA0847, mKIAA0847, SCA11.

Background: SCA11 is a 1,244 amino acid protein that belongs to the protein kinase superfamily and the CK1 Ser/Thr protein kinase family. The SCA11 gene, comprising of 16 exons, produces a 5.6-kb transcript in which the longest open reading frame is 3,732 nucleotides. Defects in the SCA11 protein are the cause of the disorder spinocerebellar ataxia type 11 (SCA11). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. The SCA11 disorder is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder. The SCA11 protein has also been implicated in Alzheimer disease and in tangle formation. Existing as three alternatively spliced isoforms, the SCA11 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken and zebrafish, and maps to human chromosome 15q15.2.