Cyclin D1 antibody (AA 108-322)

Catalog No. ABIN5027124

This Mouse Monoclonal antibody specifically detects Cyclin D1 in IHC. It exhibits reactivity toward Human.

Quick Overview for Cyclin D1 antibody (AA 108-322) (ABIN5027124)

Target: Cyclin D1 (CCND1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cyclin D1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: ABM47F5

Product Details anti-Cyclin D1 Antibody

Binding Specificity: AA 108-322

Purification: Protein G Chromatography

Immunogen: A partial length recombinant Cyclin D1 protein (amino acids 108-322) was used as the immunogen for this antibody.

Isotype: IgG2a kappa

Application Details

Application Notes: IHC: 5-10 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for Cyclin D1

Target: Cyclin D1 (CCND1)

Alternative Name: Cyclin D1

Background: Cyclin D1 (CCND1) is an important positive regulator of the G1/S phase of the cell cycle. It regulate cell cycle transition from G1 phase to S phase It is a well-established human oncogene which is frequently amplified or overexpressed in cancers (25409185). Cyclin D1b is one of two proteins translated from Cyclin D1 transcripts (isoforms a and b) that are generated due to gene polymorphism. Low Cyclin D1b expression in cervical cancer tissue, with an expression level in moderately or poorly differentiated tissues was significantly lower than that in well-differentiated tissues (25120779). Diseases associated with CCND1 include multiple myeloma and mantle cell lymphoma.

Gene ID: 23582

UniProt: O95273

Pathways: PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, ER-Nucleus Signaling