RNF31 antibody (AA 780-1020)

Catalog No. ABIN5027254

The Rabbit Polyclonal anti-RNF31 antibody is suitable to detect RNF31 in samples from Human. It has been validated for WB.

Quick Overview for RNF31 antibody (AA 780-1020) (ABIN5027254)

Target: RNF31 (Ring Finger Protein 31 (RNF31))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF31 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RNF31 Antibody

Binding Specificity: AA 780-1020

Purification: Protein A Chromatography

Immunogen: A partial length recombinant HOIP/RNF31 protein (amino acids 780-1020) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for RNF31

Target: RNF31 (Ring Finger Protein 31 (RNF31))

Alternative Name: HOIP/RNF31

Background: RNF31 (ring finger protein 31), also known as HOIP (HOIL-1-interacting protein) is an atypical E3 ubiquitin ligase that belongs to the RBR (RING-between-RING) family of E3 ligases and is the catalytic component of LUBAC (linear ubiquitin chain assembly complex), a multisubunit E3 ligase. Linear ubiquitin chains are assembled by the LUBAC (Linear Ubiquitin Chain Assembly Complex), which plays a critical role in the activation of the NF-kappaB pathway that is involved in various functions, including cell survival and inflammation. RNF31 is essential for the assembly and function of LUBAC and for various processes governing inflammation and immunity in both hematopoietic and nonhematopoietic cells.

Molecular Weight: 110 Kda

Gene ID: 55072

UniProt: Q96EP0