GBL antibody (AA 100-320)

Catalog No. ABIN5027338

The Rabbit Polyclonal anti-GBL antibody has been validated for WB. It is suitable to detect GBL in samples from Human.

Quick Overview for GBL antibody (AA 100-320) (ABIN5027338)

Target: GBL (G protein beta subunit-like (GBL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GBL antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GBL Antibody

Binding Specificity: AA 100-320

Purification: Protein A Chromatography

Immunogen: A partial length recombinant LST8/GBL protein (amino acids 100-320) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 1-3 μg/mL.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for GBL

Target: GBL (G protein beta subunit-like (GBL))

Alternative Name: LST8/GBL

Background: MLST8 or GbL (G protein beta protein subunit-like) is a subunit of mTORC1 and mTORC2 which regulates cell growth and survival. Both mTORC1 and 2 are activated in response to growth factors or amino acids but mTORC2 is most likely insensitive towards nutrients. Within mTORC1, LST8 interacts directly with mTOR and helps to enhance its kinase activity. mTORC1 phosphorylates EIF4EBP1 and thereby releasing it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. LST8/GBL more or less ubiquitously expressed with highest levels in skeletal muscle, heart and kidney.

Molecular Weight: 38 kDa

Gene ID: 64223

UniProt: Q9BVC4

Pathways: PI3K-Akt Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Autophagy, CXCR4-mediated Signaling Events, BCR Signaling, Warburg Effect