MYD88 antibody (AA 13-221)

Catalog No. ABIN5027489

The Mouse Monoclonal anti-MYD88 antibody (Clone ABM2H20) (ABIN5027489) specifically detects MYD88 in WB and FACS. The antibody is reactive with Human samples.

Quick Overview for MYD88 antibody (AA 13-221) (ABIN5027489)

Target: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MYD88 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: ABM2H20

Product Details anti-MYD88 Antibody

Binding Specificity: AA 13-221

Purification: Protein G Chromatography

Immunogen: A partial length recombinant protein of human MyD88 (amino acids 13-221) was used as an immunogen for this antibody.

Isotype: IgG1 kappa

Application Details

Application Notes: WB: 0.1-0.5 μg/mL,FACS: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for MYD88

Target: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Alternative Name: MyD88

Background: MyD88 (Myeloid differentiation factor) is an essential adaptor molecule in all TLR (Toll-like receptor) signaling pathways except TLR3. MyD88 is composed of an N-terminal (Death Domain) and a highly conserved C-terminal TIR (Toll/interleukin-1 Receptor) domain. It is found to stimulate IL-1R/IL18R-mediated signaling. MyD88-dependent signaling is also important in the regulation of innate as well as acquired immunity, in particular, T-cell responses, to various microbial pathogens. After activation of TLRs, MyD88 is phosphorylated and subsequently recruits IRAKs (IL-1R Associated Kinases) and other downstream proteins such as TRAF6, finally resulting in activation of the NF-kappaB (nuclear factor kappa B) pathway.

Molecular Weight: 33 kDa

Gene ID: 4615

UniProt: Q99836

Pathways: NF-kappaB Signaling, TLR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades