TAB3 antibody (AA 1-385)

Catalog No. ABIN5027557

The Rabbit Polyclonal anti-TAB3 antibody is suitable to detect TAB3 in samples from Human. It has been validated for WB.

Quick Overview for TAB3 antibody (AA 1-385) (ABIN5027557)

Target: TAB3 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 3 (TAB3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAB3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TAB3 Antibody

Binding Specificity: AA 1-385

Purification: Protein A Chromatography

Immunogen: A partial length recombinant TAB3 protein (amino acids 1-350) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 4-6 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for TAB3

Target: TAB3 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 3 (TAB3))

Alternative Name: TAB3

Background: TAB3 (TGF-beta activated kinase 1/MAP3K7 binding protein 3) has CUE domain and RanBP2-type zinc finger (NZF) domains mediates binding to two consecutive 'Lys-63'-linked ubiquitins. It contains 712 amino acids. TAB3 is a mediator of MAP3K7 activation and it forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation of TNF or IL-1. This successive MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor and AP1 transcription factor. This protein shows interaction with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. It has 2 isoforms produced by alternative splicing. Isoform 2 may be an oncogenic factor. TAB3 involved in necrosis and tumors like disease.

Molecular Weight: 80 kDa

Gene ID: 257397

UniProt: Q8N5C8

Pathways: TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades