VAV2 antibody (AA 610-824)

Catalog No. ABIN5027629

The Rabbit Polyclonal anti-VAV2 antibody has been validated for WB. It is suitable to detect VAV2 in samples from Human.

Quick Overview for VAV2 antibody (AA 610-824) (ABIN5027629)

Target: VAV2 (Vav 2 Guanine Nucleotide Exchange Factor (VAV2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VAV2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-VAV2 Antibody

Binding Specificity: AA 610-824

Purification: Protein A Chromatography

Immunogen: A partial length recombinant VAV2 protein (amino acids 610-824) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 1-2 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for VAV2

Target: VAV2 (Vav 2 Guanine Nucleotide Exchange Factor (VAV2))

Alternative Name: VAV2

Background: Vav2 is a member of the Vav family that serves as a GRF (guanine nucleotide exchange factor) for the Rho family of Ras-related GTPases. It is widely expressed and regulates processes including cell migration, neuronal development and phagocytosis through interactions with different proteins. Vav2, a GEF for Rac1, RhoA, and Cdc42, is shown to be regulated by a phosphorylation-dependent interaction with PKL (Paxillin kinase linker). PKL is required for Vav2 activation downstream of integrin engagement and epidermal growth factor (EGF) stimulation. During the process of spinal neurons, the Vav2 activity is necessary for optimal neurite outgrowth and promotes branching by targeting GEF activity to branch points.

Molecular Weight: 90 kDa

Gene ID: 7410

UniProt: P52735

Pathways: Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway