HLA-DOA antibody (N-Term)

Catalog No. ABIN5514394

Product Details anti-HLA-DOA Antibody

Target: HLA-DOA (HLA Class II DO alpha (HLA-DOA))

Binding Specificity: N-Term

Reactivity: Human, Cow, Horse, Pig, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HLA-DOA antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LMTLLSPQEA GATKADHMGS YGPAFYQSYG ASGQFTHEFD EEQLFSVDLK

Predicted Reactivity: Cow: 83%, Horse: 85%, Human: 100%, Pig: 86%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against DOA. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human DOA

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HLA-DOA

Target: HLA-DOA (HLA Class II DO alpha (HLA-DOA))

Alternative Name: DOA (HLA-DOA Products)

Synonyms: HLA-DNA antibody, HLA-DZA antibody, HLADZ antibody, major histocompatibility complex, class II, DO alpha antibody, HLA-DOA antibody

Background: HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.

Alias Symbols: HLA-DOA, HLA-DNA, HLA-DZA,

Protein Interaction Partner: REL, UBC, HLA-DMA,

Protein Size: 250

Gene ID: 3111

NCBI Accession: NP_002110

UniProt: P06340