GBA antibody (N-Term)

Catalog No. ABIN5514399

This Rabbit Polyclonal antibody specifically detects GBA in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Pig, Cow, Guinea Pig, Horse and Rabbit.

Quick Overview for GBA antibody (N-Term) (ABIN5514399)

Target: GBA (Glucosidase, Beta, Acid (GBA))

Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GBA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GBA Antibody

Binding Specificity: N-Term

Purpose: GBA Antibody - N-terminal region

Sequence: FSSPSREECP KPLSRVSIMA GSLTGLLLLQ AVSWASGARP CIPKSFGYSS

Predicted Reactivity: Cow: 75%, Dog: 75%, Guinea Pig: 75%, Horse: 75%, Human: 100%, Mouse: 75%, Pig: 79%, Rabbit: 75%, Rat: 75%

Characteristics: This is a rabbit polyclonal antibody against GLCM. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human GLCM

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP61323-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GBA

Target: GBA (Glucosidase, Beta, Acid (GBA))

Alternative Name: GBA

Background:

Background Information: This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.

Gene Name: glucosylceramidase beta

Alternative Symbols: GCB, GBA1, GLUC

Protein Name: glucosylceramidase

Molecular Weight: 58kDa

Gene ID: 2629

NCBI Accession: XP_006711333

UniProt: P04062

Pathways: Cellular Glucan Metabolic Process