beta Synuclein antibody (C-Term)

Catalog No. ABIN5514426

This Rabbit Polyclonal antibody specifically detects beta Synuclein in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Cow, Guinea Pig, Pig and Rabbit.

Quick Overview for beta Synuclein antibody (C-Term) (ABIN5514426)

Target: beta Synuclein (SNCB) (Synuclein, beta (SNCB))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This beta Synuclein antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-beta Synuclein Antibody

Binding Specificity: C-Term

Purpose: SNCB Antibody - C-terminal region

Sequence: GLVKREEFPT DLKPEEVAQE AAEEPLIEPL MEPEGESYED PPQEEYQEYE

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against SYUB. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human SNCB

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP33883-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for beta Synuclein

Target: beta Synuclein (SNCB) (Synuclein, beta (SNCB))

Alternative Name: SNCB

Background:

Background Information: The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease, however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene.

Gene Name: synuclein, beta

Alternative Symbols: SNCB, Beta-synuclein

Protein Name: Beta-synuclein

Molecular Weight: 14kDa

Gene ID: 6620

NCBI Accession: XP_006714979

UniProt: Q16143