Apolipoprotein C-II antibody (Middle Region)

Catalog No. ABIN5514502

The Rabbit Polyclonal anti-Apolipoprotein C-II antibody is suitable to detect Apolipoprotein C-II in samples from Human, Mouse, Rat, Horse, Cow, Dog and Pig. It has been validated for WB.

Quick Overview for Apolipoprotein C-II antibody (Middle Region) (ABIN5514502)

Target: Apolipoprotein C-II (APOC2)

Reactivity: Human, Mouse, Rat, Horse, Cow, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Apolipoprotein C-II antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Apolipoprotein C-II Antibody

Binding Specificity: Middle Region

Purpose: APOC2 Antibody - middle region

Sequence: ESAKTAAQNL YEKTYLPAVD EKLRDLYSKS TAAMSTYTGI FTDQVLSVLK

Predicted Reactivity: Cow: 86%, Dog: 86%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 86%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against APOC2. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human APOC2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP54318-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Apolipoprotein C-II

Target: Apolipoprotein C-II (APOC2)

Alternative Name: APOC2

Background:

Background Information: This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene.

Gene Name: apolipoprotein C-II

Alternative Symbols: APO-CII, APOC-II

Protein Name: Apolipoprotein C-II

Molecular Weight: 11kDa

Gene ID: 344

NCBI Accession: NP_000474

UniProt: P02655

Pathways: Lipid Metabolism