Cytohesin 2 antibody (C-Term)

Catalog No. ABIN5514510

This Rabbit Polyclonal antibody specifically detects Cytohesin 2 in WB. It exhibits reactivity toward Human, Rat, Mouse, Dog, Cow, Guinea Pig, Horse, Sheep, Rabbit and Zebrafish (Danio rerio).

Quick Overview for Cytohesin 2 antibody (C-Term) (ABIN5514510)

Target: Cytohesin 2 (CYTH2)

Reactivity: Human, Rat, Mouse, Dog, Cow, Guinea Pig, Horse, Sheep, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cytohesin 2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Cytohesin 2 Antibody

Binding Specificity: C-Term

Sequence: GRVKTWKRRW FILTDNCLYY FEYTTDKEPR GIIPLENLSI REVDDPRKPN

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against CYTH2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human CYTH2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Cytohesin 2

Target: Cytohesin 2 (CYTH2)

Alternative Name: CYTH2

Background: The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83 % homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.

Alias Symbols: ARNO, CTS18, CTS18.1, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like

Protein Interaction Partner: CCDC120, UBC, ARF6, GNAQ, PNPLA2, DYT10, MAPK6, APC, IPCEF1, ATP6V0A2, CYTIP, ARFGAP1, TRIM23, ITGB2, PRKCG, PRKCB, PRKCA, CUX1, ARRB2, ARRB1, ARF1, ADORA2A, ARF3, SFN,

Protein Size: 400

Gene ID: 9266

NCBI Accession: NM_017457, NP_059431

UniProt: Q99418