ATP7B antibody (Middle Region)

Catalog No. ABIN5514518

The Rabbit Polyclonal anti-ATP7B antibody (ABIN5514518) specifically detects ATP7B in WB. The antibody is reactive with Human, Mouse, Rat, Dog, Guinea Pig, Horse and Rabbit samples.

Quick Overview for ATP7B antibody (Middle Region) (ABIN5514518)

Target: ATP7B (ATPase, Cu++ Transporting, beta Polypeptide (ATP7B))

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATP7B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ATP7B Antibody

Binding Specificity: Middle Region

Purpose: ATP7B Antibody - middle region

Sequence: IIMSTLTLVV WIVIGFIDFG VVQRYFPNPN KHISQTEVII RFAFQTSITV

Predicted Reactivity: Dog: 82%, Guinea Pig: 82%, Horse: 82%, Human: 100%, Mouse: 91%, Rabbit: 92%, Rat: 91%

Characteristics: This is a rabbit polyclonal antibody against ATP7B. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ATP7B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP44524-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for ATP7B

Target: ATP7B (ATPase, Cu++ Transporting, beta Polypeptide (ATP7B))

Alternative Name: ATP7B

Background:

Background Information: This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).

Gene Name: ATPase copper transporting beta

Alternative Symbols: WD, PWD, WC1, WND

Protein Name: copper-transporting ATPase 2

Molecular Weight: 74kDa

Gene ID: 540

NCBI Accession: NP_000044

UniProt: P35670

Pathways: Transition Metal Ion Homeostasis, Ribonucleoside Biosynthetic Process