COMP antibody (N-Term)

Catalog No. ABIN5514649

The Rabbit Polyclonal anti-COMP antibody is suitable to detect COMP in samples from Mouse, Human, Rat, Dog, Horse, Pig and Cow. It has been validated for WB.

Quick Overview for COMP antibody (N-Term) (ABIN5514649)

Target: COMP (Cartilage Oligomeric Matrix Protein (COMP))

Reactivity: Mouse, Human, Rat, Dog, Horse, Pig, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COMP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-COMP Antibody

Binding Specificity: N-Term

Purpose: COMP Antibody - N-terminal region

Sequence: CVLLLTLAAL GASGQGQSPL GSDLGPQMLR ELQETNAALQ DVRELLRQQV

Predicted Reactivity: Cow: 93%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against COMP. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human COMP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP41670-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for COMP

Target: COMP (Cartilage Oligomeric Matrix Protein (COMP))

Alternative Name: COMP

Background:

Background Information: The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).

Gene Name: cartilage oligomeric matrix protein

Alternative Symbols: MED, CTS2, EDM1, EPD1, TSP5, PSACH, THBS5

Protein Name: Cartilage oligomeric matrix protein

Molecular Weight: 83kDa

Gene ID: 1311

NCBI Accession: NP_000086

UniProt: P49747