SIRT3 antibody (N-Term)

Catalog No. ABIN5514670

The Rabbit Polyclonal anti-SIRT3 antibody is suitable to detect SIRT3 in samples from Human. It has been validated for WB.

Quick Overview for SIRT3 antibody (N-Term) (ABIN5514670)

Target: SIRT3 (Sirtuin 3 (SIRT3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIRT3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SIRT3 Antibody

Binding Specificity: N-Term

Purpose: SIRT3 Antibody - N-terminal region

Sequence: AAAPSFFFSS IKGGRRSISF SVGASSVVGS GGSSDKGKLS LQDVAELIRA

Characteristics: This is a rabbit polyclonal antibody against SIR3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human SIR3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP74220-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SIRT3

Target: SIRT3 (Sirtuin 3 (SIRT3))

Alternative Name: SIRT3

Background:

Background Information: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.

Gene Name: sirtuin 3

Alternative Symbols: SIR2L3

Protein Name: NAD-dependent protein deacetylase sirtuin-3, mitochondrial

Molecular Weight: 43kDa

Gene ID: 23410

NCBI Accession: NP_036371

UniProt: Q9NTG7