TPP1 antibody (C-Term)

Catalog No. ABIN5514672

This Rabbit Polyclonal antibody specifically detects TPP1 in WB. It exhibits reactivity toward Human.

Quick Overview for TPP1 antibody (C-Term) (ABIN5514672)

Target: TPP1 (Tripeptidyl Peptidase I (TPP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TPP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TPP1 Antibody

Binding Specificity: C-Term

Sequence: QHGAGLFDVT RGCHESCLDE EVEGQGFCSG PGWDPVTGWG TPNFPALLKT

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TPP1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TPP1

Target: TPP1 (Tripeptidyl Peptidase I (TPP1))

Alternative Name: TPP1

Background: This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.

Alias Symbols: CLN2, GIG1, LPIC, SCAR7, TPP-1

Protein Size: 563

Gene ID: 1200

NCBI Accession: NM_000391, NP_000382

UniProt: O14773

Pathways: Cell Division Cycle, ER-Nucleus Signaling