Phospholipase C gamma 2 antibody (Middle Region)

Catalog No. ABIN5514741

This Rabbit Polyclonal antibody specifically detects Phospholipase C gamma 2 in WB. It exhibits reactivity toward Human, Rat, Mouse, Cow, Dog, Horse, Rabbit and Guinea Pig.

Quick Overview for Phospholipase C gamma 2 antibody (Middle Region) (ABIN5514741)

Target: Phospholipase C gamma 2 (PLCG2)

Reactivity: Human, Rat, Mouse, Cow, Dog, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Phospholipase C gamma 2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Phospholipase C gamma 2 Antibody

Binding Specificity: Middle Region

Sequence: ETHLRCAEFE LRLTDPVPNP NPHESKPWYY DSLSRGEAED MLMRIPRDGA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PLCG2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human PLCG2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Phospholipase C gamma 2

Target: Phospholipase C gamma 2 (PLCG2)

Alternative Name: PLCG2

Background: The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane.

Alias Symbols: PLCG2,

Protein Interaction Partner: UBC, ZNF512B, ERBB2, EGFR, PRKCA, PLD1, IRS1, BLNK, LAT2, LIME1, GAB2, DAPP1, PRKD1, CBLB, GAB1, KHDRBS1, LAT, SH3BP2, LCP2, TEC, SHC1, PLCG2, SYK, BTK, KDR, BLK, ITK, LYN, FLT1, NPM1, LCK, JAK2, JAK1, FCER1G, HCK, FYN, EPOR, CD19, PLXNB1, VAV1, PTPN11,

Protein Size: 1265

Gene ID: 5336

NCBI Accession: NM_002661, NP_002652

UniProt: P16885

Pathways: RTK Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, Inositol Metabolic Process, Myometrial Relaxation and Contraction, Toll-Like Receptors Cascades, VEGF Signaling, BCR Signaling