GPS2 antibody (C-Term)

Catalog No. ABIN5514785

The Rabbit Polyclonal anti-GPS2 antibody (ABIN5514785) specifically detects GPS2 in WB. The antibody is reactive with Human samples.

Quick Overview for GPS2 antibody (C-Term) (ABIN5514785)

Target: GPS2 (G Protein Pathway Suppressor 2 (GPS2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPS2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GPS2 Antibody

Binding Specificity: C-Term

Sequence: TAQPPPHYGP TQPAYSPSQQ LRAPSAFPAV QYLSQPQPQP YAVHGHFQPT

Characteristics: This is a rabbit polyclonal antibody against GPS2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human GPS2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GPS2

Target: GPS2 (G Protein Pathway Suppressor 2 (GPS2))

Alternative Name: GPS2

Background: This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.

Alias Symbols: GPS2,

Protein Interaction Partner: ATF4, TFIP11, RBPMS, RALBP1, KRT31, SESTD1, NCOR2, HDAC3, SUMO1, UBC, TBL1X, TBL1XR1, vif, MSH5, MSH4, Nr0b2, NR1H4, HNF4A, HDAC1, NR5A2, HDAC5, THRB, THRA, CNOT2, SIN3A, PBK, C19orf57, GPS2, MAP3K7CL, CHD3, SPDL1, SETDB1, CCNA1, EP300, GOLGA2, NCOR1, TP5

Protein Size: 327

Gene ID: 2874

NCBI Accession: XP_005256674

UniProt: Q13227