TDO2 antibody (C-Term)

Catalog No. ABIN5514793

The Rabbit Polyclonal anti-TDO2 antibody is suitable to detect TDO2 in samples from Human, Mouse, Rat, Dog, Cow, Guinea Pig, Rabbit, Zebrafish (Danio rerio) and Horse. It has been validated for WB.

Quick Overview for TDO2 antibody (C-Term) (ABIN5514793)

Target: TDO2 (Tryptophan 2,3-Dioxygenase (TDO2))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Rabbit, Zebrafish (Danio rerio), Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TDO2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TDO2 Antibody

Binding Specificity: C-Term

Purpose: TDO2 Antibody - C-terminal region

Sequence: MDIDSLMTKW RYNHVCMVHR MLGSKAGTGG SSGYHYLRST VSDRYKVFVD

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against T23O. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human T23O

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45718-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for TDO2

Target: TDO2 (Tryptophan 2,3-Dioxygenase (TDO2))

Alternative Name: TDO2

Background:

Background Information: This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.

Gene Name: tryptophan 2,3-dioxygenase

Alternative Symbols: TO, TDO, TPH2, TRPO, HYPTRP

Protein Name: tryptophan 2,3-dioxygenase

Molecular Weight: 44kDa

Gene ID: 6999

NCBI Accession: NP_005642

UniProt: P48775