ITM2B antibody (N-Term)

Catalog No. ABIN5514896

The Rabbit Polyclonal anti-ITM2B antibody (ABIN5514896) specifically detects ITM2B in WB. The antibody is reactive with Human samples.

Quick Overview for ITM2B antibody (N-Term) (ABIN5514896)

Target: ITM2B (Integral Membrane Protein 2B (ITM2B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITM2B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ITM2B Antibody

Binding Specificity: N-Term

Purpose: ITM2B Antibody - N-terminal region

Sequence: FNSALAQKEA KKDEPKSGEE ALIIPPDAVA VDCKDPDDVV PVGQRRAWCW

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ITM2B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP78186-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for ITM2B

Target: ITM2B (Integral Membrane Protein 2B (ITM2B))

Alternative Name: ITM2B

Background:

Background Information: Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

Gene Name: integral membrane protein 2B

Alternative Symbols: BRI, FBD, ABRI, BRI2, E25B, E3-16, RDGCA, imBRI2, BRICD2B

Protein Name: integral membrane protein 2B

Molecular Weight: 29 kDa

Gene ID: 9445

NCBI Accession: NP_068839

UniProt: Q9Y287