RAB43 antibody (C-Term)

Catalog No. ABIN5515092

This Rabbit Polyclonal antibody specifically detects RAB43 in WB. It exhibits reactivity toward Human.

Quick Overview for RAB43 antibody (C-Term) (ABIN5515092)

Target: RAB43 (RAB43, Member RAS Oncogene Family (RAB43))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAB43 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RAB43 Antibody

Binding Specificity: C-Term

Sequence: ETSAKDSSNV EEAFLRVATE LIMRHGGPLF SEKSPDHIQL NSKDIGEGWG

Characteristics: This is a rabbit polyclonal antibody against RAB43. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human RAB43

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RAB43

Target: RAB43 (RAB43, Member RAS Oncogene Family (RAB43))

Alternative Name: RAB43

Background: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. RAB43 is involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. It plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

Alias Symbols: RAB41

Protein Size: 212

Gene ID: 339122

NCBI Accession: NP_940892

UniProt: Q86YS6