Stanniocalcin 2 antibody (N-Term)

Catalog No. ABIN5515182

This Rabbit Polyclonal antibody specifically detects Stanniocalcin 2 in WB. It exhibits reactivity toward Human.

Quick Overview for Stanniocalcin 2 antibody (N-Term) (ABIN5515182)

Target: Stanniocalcin 2 (STC2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Stanniocalcin 2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Stanniocalcin 2 Antibody

Binding Specificity: N-Term

Purpose: STC2 Antibody - N-terminal region

Sequence: ATFDPARGTD ATNPPEGPQD RSSQQKGRLS LQNTAEIQHC LVNAGDVGCG

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human STC2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP81268-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Stanniocalcin 2

Target: Stanniocalcin 2 (STC2)

Alternative Name: STC2

Background:

Background Information: This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.

Gene Name: stanniocalcin 2

Alternative Symbols: STC-2, STCRP

Protein Name: stanniocalcin-2

Molecular Weight: 33 kDa

Gene ID: 8614

NCBI Accession: NP_003705

UniProt: O76061

Pathways: Hormone Activity, ER-Nucleus Signaling, SARS-CoV-2 Protein Interactome